The average age for an MI is 60, and the researchers found that their model achieved its best predictive performance more than five years before the MI event. In the future, a simple retinal examination may be able to provide enough information to identify people at risk. Once we validated our MI definition, we found that our model worked extremely well,” Ms Villaplana-Velasco said. In our case, we found that the clinical MI definition - the diagnostic codes that describe myocardial infarction events in medical records - is central to the successful development of predictive models, underpinning the need for developing robust disease definitions in large studies such as UKB. “There have been multiple attempts to improve CAD and MI risk predictive models by accounting for retinal vascular traits, but these showed no significant improvement when compared with established models. We would like to repeat our analysis separately in males and females to investigate if a sex-specific model for MI completes a better risk classification,” says Ms Villaplana-Velasco.Įven though the researchers knew that variations in retinal vasculature were associated with the state of health of an individual, their convincing results came as a surprise. We know that females with a higher MI or CAD risk tend to have pronounced retinal vascular deviations when compared to the male population. “We would like to investigate this further, as well as undertaking a sex-specific analysis. The researchers believe it is possible that every condition may have a unique retinal variation profile. Variations in the retinal vascular pattern also reflect the development of other ocular and systemic diseases, such as diabetic retinopathy and stroke. These findings may also be useful in identifying propensity to other diseases. In particular, we found that these common genetic regions are involved in processes related to MI severity and recovery.” Four of these regions are known to be involved in cardiovascular disease genetics. “We wondered if the Df-MI association was influenced by shared biology, so we looked at the genetics of Df and found nine genetic regions driving retinal vascular branching patterns. The improvement of our model was even higher if we added a score related to the genetic propensity of developing MI”, Ms Villaplana-Velasco said. “Strikingly, we discovered that our model was able to better classify participants with low or high MI risk in UKB when compared with established models that only include demographic data. The model included Df as well as traditional clinical factors, such as age, sex, systolic blood pressure, body mass index and smoking status to calculate personalised MI risk. The researchers then developed a model that was able to predict MI risk prediction by studying UKB participants who had experienced an MI event after collection of their retinal images. We found that lower Df, simplified vessel branching patterns, is related to CAD and hence MI,” says Ms Ana Villaplana-Velasco, a PhD student at the Usher and Roslin Institutes, University of Edinburgh, Edinburgh, UK. UKB includes demographical, epidemiological, clinical, imaging and genotyping data from over 500,000 participants across UK. First, we studied the branching patterns of the retinal vasculature by calculating a measure named fractal dimension (Df) from data available from the UK Biobank (UKB). Given that retinal imaging is a non-invasive technique, we decided to investigate the health benefits we could obtain from these images. “We already knew that variations in the vasculature of the retina might offer insights into our health. The discovery could lead to a simple screening process where an MI risk could be calculated when a person undergoes a routine eye test, researchers will tell the annual conference of the European Society of Human Genetics today (Monday). Vienna, Austria: Combining information about the pattern of blood vessels in the retina with genetic data can enable accurate prediction of an individual’s risk of coronary artery disease (CAD) and its potentially fatal outcome, myocardial infarction (MI), commonly known as a heart attack. Genetics and Medicine Historical Network.
#Passport to purity travel journal professional
Public and Professional Policy Committee.
#Passport to purity travel journal series
0 kommentar(er)
